Anti-alpha2C-Adrenoceptor (ext.)

Antibodies

Alpha-2C adrenoceptor, Alpha-2C adrenoreceptor, Alpha-2CAR, ADA2C, ADRA2C

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4

Alpha-2C adrenoceptor, Alpha-2C adrenoreceptor, Alpha-2CAR, ADA2C, ADRA2C - A Rabbit Polyclonal Antibody to α2C-Adrenergic Receptor

Rat, mouse - 15/16 amino acid residues identical; human - 14/16 amino acid residues identical

Confirmed by amino acid analysis and mass spectrometry

0.8 mg/ml

2nd extracellular loop

Rat

41116161

Adrenergic receptors (also called adrenoceptors) are the receptors for the catecholamines adrenaline and noradrenaline (called epinephrine and norepinephrine in the United States). Adrenaline and noradrenaline play important roles in the control of blood pressure, myocardial contractile rate and force, airway reactivity, and a variety of metabolic and central nervous system functions.Adrenergic receptors are members of the G-protein coupled receptor (GPCR) superfamily of membrane proteins. They share a common structure of seven putative transmembrane domains, an extracellular N-terminus, and a cytoplasmic C- terminus.Adrenoceptors are divided into three types: α1, α2 and β-adrenoceptors. Each type is further divided into at least three subtypes: α1A, α1B, α1D, α2A, α2B, α2C, β1, β2, β31, 2. Adrenoceptors are expressed in nearly all peripheral tissues and in the central nervous system1, 2.The α2C-adrenoceptor subtype was identified by binding studies in the opossum kidney and in cell lines from this organ (OK cells)3, 4.Surprisingly, the α2C-adrenoceptor subtype seems not to play a major role in cardiovascular regulation or the other classical effects of α2-adrenergic receptors5. Some researchers have suggested that the α2C-adrenoceptor subtype may play a role in modulating motor behaviour and perhaps in memory processes6.