Anti-Human C5aR1 (extracellular)

IFC, LCI, WB

C5a1 receptor, C5a anaphylatoxin chemotactic receptor 1, C5a anaphylatoxin receptor, C5R1, Complement component 5a receptor 1, CD88

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4

C5a1 receptor, C5a anaphylatoxin chemotactic receptor 1, C5a anaphylatoxin receptor, C5R1, Complement component 5a receptor 1, CD88 - A Rabbit Polyclonal Antibody to C5a Anaphylatoxin Receptor

Human only Not recommended for use with rat and mouse samples

Confirmed by amino acid analysis and mass spectrometry

1 mg/ml

Extracellular, N-terminus

Human

41116161

The innate immune system identifies pathogens by recognizing known elements. This response ultimately leads to the production of proinflammatory substances and the activation of phagocytic neutrophils and macrophages1. Activation of the complement system is an important initial even in the response against pathogens. This system includes some thirty different proteins that act together to form a complex1.C5a is one of the most potent inflammatory peptides generated by complement activation. This peptide has many functions such as acting as a chemoattractant for neutrophils2, 3. C5a acts as a vasodilator3, 4 and activates the coagulation pathway3, 5 just to name a few.C5a exerts its numerous actions by binding to C5aR and C5L2. C5aR belongs to the superfamily of G-protein coupled receptors (GPCRs). Like all members, C5aR has seven transmembrane domains, an extracellular N-terminus and an intracellular C-terminal tail. C5aR can form homodimers6-8 or heteromer with CCR5, chemokine receptor, for example8, 9. Activation of C5aR by C5a binding causes Ca2+ mobilization10.C5aR expression is detected in neutrophils, eisinophils, basophils and monocytes3, 11, 12. The receptor is also expressed in lung and liver13, 14.Blocking C5aR by peptides or organic small molecules is in the pipeline for treating chronic inflammatory disorders/diseases like arthritis, inflammatory bowel disease and lung/liver injuries8.