Anti-CaVpan alpha1

ArtNr	ALO-ACC-004-50ul
Hersteller	Alomone
Menge	50 ul
Quantity options	0.2 ml 50 ul
Kategorie	Neuroscience Molecular Targets for Neuroscience Antibodies Immunohistochemistry Immunoprecipitation Western Blot Immunofluorescence Cardiovascular Research Hypertension Primary Antibodies
Typ	Antibody Polyclonal
Format	Lyophilized
Applikationen	WB, IF, IP, IHC
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Purity	Affinity purified on immobilized antigen.
Formula	PBS pH7.4, 1% BSA with 0.05% sodium azide
Sequence	(C)DNFDYLTRDWSILGPHHLD, corresponding to amino acid residues 1506-1524 of rat CaV1.2
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Versandbedingung	Raumtemperatur
Lieferbar
Specificity	Polyclonal
Manufacturer - Type	Antibodies
Manufacturer - Category	Antibodies
Manufacturer - Targets	Voltage-dependent L-type calcium channel subunit alpha-1C, Cacna1c
Country of Origin	Israel
Shipping Temperature	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Storage Conditions	Storage before Reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C - Storage after Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Manufacturer - Format	Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4
Short description	A Rabbit Pan Polyclonal Antibody to CaV1 and CaV2 Subunits
Description	Voltage-dependent L-type calcium channel subunit alpha-1C, Cacna1c - A Rabbit Pan Polyclonal Antibody to CaV1 and CaV2 Subunits
Clonality	Polyclonal
Homology	CaV1 family (α1C, α1D, α1F, α1S) from all known species - identical; CaV2 family (α1A, α1B, α1E) from all known species - 17/19 amino acid residues identical
Standard quality control of each lot	Western blot analysis
Peptide confirmation	Confirmed by amino acid analysis and mass spectrometry
Reconstitution	50 µl or 0.2 ml double distilled water (DDW), depending on the sample size.
Antibody Concentration After Reconstitution	0.8 mg/ml
Preservative	1% BSA, 0.05% NaN3
Immunogen Location	Intracellular, C-terminal region.
Specificity	CACNA1C
Immunogen source species	Rat
PH	7, 4
UNSPSC	41116161
Antigen Preadsorption Control	1 µg peptide per 1 µg antibody
Scientific Background	Ca2+ ions regulate many cellular processes such as secretion, proliferation, and apoptosis and they are also cofactors of many proteins.1, 2 In neurons, Ca2+ entry through voltage-dependent Ca2+ (CaV) channels triggers neurotransmitter release. Fast synaptic transmission in the mammalian central nervous system (CNS) is mediated by several high voltage-dependent Ca2+ channels.3Five types of Ca2+ channels are expressed in the CNS: the L-type (CaV1), N-type (CaV2.2), P/Q-type (CaV2.1), R-type (CaV2.3), and the T-type (CaV3).4 Each CaV channel is a multimeric protein composed of a pore forming α1 subunit and the auxiliary β (CaVβ), α2δ and γ subunits. There are four known CaVβ subunits, in addition to four α2δ subunits and eight γ subunits.4

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