Anti-CLC-5

ArtNr	ALO-ACL-003-50ul
Hersteller	Alomone
Menge	50 ul
Quantity options	0.2 ml 50 ul
Kategorie	Metabolism Diabetes Antibodies Immunohistochemistry Western Blot Primary Antibodies
Typ	Antibody Polyclonal
Format	Lyophilized
Applikationen	WB, IHC
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Purity	Affinity purified on immobilized antigen.
Formula	PBS pH7.4, 1% BSA with 0.05% sodium azide
Sequence	CDYENHFNTSKGGEL, corresponding to amino acid residues 401-415 of rat CLCN5
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Versandbedingung	Raumtemperatur
Lieferbar
Specificity	Polyclonal
Manufacturer - Type	Antibodies
Manufacturer - Category	Antibodies
Manufacturer - Targets	CLCN5, Chloride channel 5, Chloride transporter ClC-5, H+/Cl- exchange transporter 5, DENTS
Country of Origin	Israel
Shipping Temperature	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Storage Conditions	Storage before Reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C - Storage after Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Manufacturer - Format	Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4
Short description	A Rabbit Polyclonal Antibody to CLC-5 (CLCN5) Channel
Description	CLCN5, Chloride channel 5, Chloride transporter ClC-5, H+/Cl- exchange transporter 5, DENTS - A Rabbit Polyclonal Antibody to CLC-5 (CLCN5) Channel
Clonality	Polyclonal
Homology	Mouse - identical; human - 14/15 amino acid residues identical
Standard quality control of each lot	Western blot analysis
Peptide confirmation	Confirmed by amino acid analysis and mass spectrometry
Reconstitution	50 μl or 0.2 ml double distilled water (DDW), depending on the sample size.
Antibody Concentration After Reconstitution	0.8 mg/ml
Preservative	1% BSA, 0.05% NaN3
Immunogen Location	Extracellular
Specificity	CLCN5
Immunogen source species	Rat
PH	7, 4
UNSPSC	41116161
Antigen Preadsorption Control	1 µg peptide per 1 µg antibody
Scientific Background	CLC5 is a member of the voltage-dependent Cl- channel family that includes nine known members. Based on sequence similarity, CLC5 is closely linked to the CLC3 and CLC4 subunits. CLC-5 is mainly found in intracellular vesicles, particularly in early endosomes, where it is believed to contribute to their acidification.The channel is mainly expressed in the kidney, although it has also been found in the small intestine, brain and liver.Mutations in the CLC5 gene cause Dent's disease, an X-linked renal disorder.

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ALO-ACL-003-50ul-safety-datasheet.pdf