Anti-Urotensin II Receptor

Antibodies

Urotensin 2 receptor, UR-II-R, UR2R, UTS2R, SENR, GPR14

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4

Urotensin 2 receptor, UR-II-R, UR2R, UTS2R, SENR, GPR14 - A Rabbit Ployclonal Antibody to Urotensin II Receptor

Bovine - identical; human, canine - 13/14 amino acid residues identical

Confirmed by amino acid analysis and mass spectrometry

1 mg/ml

2nd intracellular loop

Rat

41116161

Urotensin II is a powerful vasoconstrictive substance. The human urotensin II receptor (UR-II-R) was originally isolated as an orphan receptor (GPR14) from neural and sensory tissues.1, 2 Urotensin II is expressed in various human tissues such as the CNS, skeletal muscle, smooth muscle, pancreas, and heart.3-5 Binding of urotensin II to the receptor leads to activation of phospholipase C. The resulting increase in intracellular Ca2+ may cause the contraction of vascular smooth muscle. ERK1/2 phophorylation may also be involved in mediating the biological activities of urotensin II.6 Recently, evidence has accumulated indicating that urotensin II is also expressed in various kinds of tumor cells such as adrenal tumors and neuroblastomas. In those cells, urotensin II was reported to stimulate cell growth.7-9