Anti-Ghrelin Receptor (extracellular)–FITC

Antibodies

Fluorescein isothiocyanate (FITC).

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Lyophilized powder

Growth hormone secretagogue receptor type 1, GHS-R, GH-releasing peptide receptor, GHRP - A Rabbit Polyclonal Antibody to Ghrelin Receptor (GHSR) Conjugated to the Fluorescent Dye FITC

Mouse - identical; human - 10 out of 11 amino acid residues identical

Confirmed by amino acid analysis and mass spectrometry

1 mg/ml

2nd extracellular loop

Rat

41116161

Ghrelin is a 28 amino acid peptide, acylated on a serine residue which is essential for its biological activity1, 2. In rodents, an additional form of the peptide could be purified. The peptide is released from the stomach and exerts its effect on the ghrelin receptor (GHS-R). GHS-R is a member of the G-protein coupled receptor (GPCR) superfamily. Like all members, the receptor has seven transmembrane spanning domains and upon activation it stimulates phospholipase C, thereby increasing IP3 and intracellular Ca2+ levels1, 3.GHS-R is expressed in the hypothalamus, pituitary and hippocampus1, 3.Some of the actions of ghrelin include the stimulation of growth hormone release, food intake, fat accumulation, regulation of memory and learning, activation of reward-related pathways and neuroprotection to name a few1, 3.GHS-R 1b is a truncated form of the full length receptor which is also expressed. Although its exact functions are unknown, it is believed that it may be involved in downregulating signaling from the full length receptor4. In addition, it is overexpressed in lung cancer where it dimerizes with neurotensin receptor4, 5.