Anti-KISS1 Receptor (extracellular)

IF, IFC, IHC, LCI, WB

Kisspeptin receptor, KISS1R, Metastin receptor, AXOR12

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4

Kisspeptin receptor, KISS1R, Metastin receptor, AXOR12 - A Rabbit Polyclonal Antibody to Kisspeptin Receptor

Rat - 13/14 amino acid residues identical; mouse - 12/14 amino acid residues identical

Confirmed by amino acid analysis and mass spectrometry

0.8 mg/ml

3rd extracellular loop

Human

41116161

The kisspeptin receptor (KISS1R, GPCR54) is a member of the G-protein coupled receptor superfamily. KISS1R natural ligands are peptides called kisspeptins which are encoded by the Kiss1 gene. The Kiss1 gene was originally discovered by Hershey scientists who named it after their famous chocolate, the "Kiss".The kisspeptins, acting through KISS1R, were found to be potent inhibitors of metastasis in a variety of cancer cell types including thyroid and pancreatic cancer cells. KISS1R and kisspeptins are involved in the direct regulation of the reproductive neuroendocrine axis.KISS1R is widely distributed throughout the brain, where it is most highly expressed in the hypothalamic and amygdaloid nuclei. High expression was also found in the pancreas and placenta. Lower-level expression was found in a variety of other peripheral tissues including peripheral blood leukocytes, kidney, lung, testes, spleen, thymus, adrenal glands and lymph nodes.1-3