Anti-P2X7 Receptor (extracellular)-PE

Antibodies

R-Phycoerythrin (R-PE).

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Lyophilized powder

Purinergic receptor P2X7, P2RX7, P2Z, ATP receptor - A Rabbit Polyclonal Antibody to P2X7 Conjugated to the Fluorescent Dye Phycoerythrin

Human, rat - identical; bovine - 14/17 amino acid residues identical

Confirmed by amino acid analysis and mass spectrometry

1 mg/ml

Extracellular loop

Mouse

41116161

The P2X7 receptor is a member of the ionotropic P2X receptor family that is activated by ATP. To date, this family is composed of seven cloned receptor subtypes, named P2X1-P2X7.The different P2X receptors show distinct expression patterns. P2X1-6 have been found in the central and peripheral nervous system, while the P2X7 receptor is found in cells of the immune system, particularly antigen presenting cells, and microglia. The P2X7 receptor mediates the release of proinflammatory cytokines, stimulation of transcription factors and may also have an important role in apoptosis1-3.Different techniques have been used to characterize the P2X7 receptor. Most of them investigated pores, ion channels (electrophysiology) and membrane alterations (calcium microfluorometry, dye uptake, membrane depolarization, and ion influx analysis). With the introduction of flow cytometry, it is now possible to analyze multiple cell parameters such as cell cycle, cell membrane alteration, calcium influx, and cell phenotype4.