Anti-pan ASIC (extracellular)

IC, IF, IFC, IHC, LCI, WB

Acid-sensing ion channel, Acid-sensing (proton-gated) ion channel, ACCN, ACCN2, ACCN3, ACCN4

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4

Acid-sensing ion channel, Acid-sensing (proton-gated) ion channel, ACCN, ACCN2, ACCN3, ACCN4 - A Rabbit Polyclonal Antibody to ASIC Channels (ASIC1, ASIC2, ASIC3, ASIC4)

ASIC1: Mouse, rat, human - identicalASIC2: Mouse, rat, human - 14/15 amino acid residues identicalASIC3: Mouse, rat, human - 12/15 amino acid residues identicalASIC4: Mouse, rat - 12/15 amino acid residues identical; human - 11/15 amino acid residues identical

Confirmed by amino acid analysis and mass spectrometry

0.8 mg/ml

Extracellular loop

Rat

41116161

ASIC channels belong to the ENaC/Degenerin superfamily and are proton-gated ion channels which are not voltage-dependent. Six different genes encode the different ASIC subunits and splice variants: ASIC1a, ASIC1b, ASIC2a, ASIC2b, ASIC3 and ASIC4.ASIC channels sense protons and interact with proteins (namely proteases) and other ions such as Zn2+ and Ca2+ through their extracellular domains. The extracellular loop of ASIC1a undergoes cleavage by extracellular trypsin (a serine protease) which is responsible for shifting the pH dependence of the channel activation and inactivation to more acidic pH1.These channels are expressed in the brain and in the nervous system2 but have also been found in the retina, testes, and other tissues3, 4 where they are involved in many physiological processes including nociception5, learning and memory6, mechanosensation7 among others.