Anti-Zinc Transporter ZIP3

Antibodies

Zinc transporter ZIP3, Zrt- and Irt-like protein 3

Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C

Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4

Zinc transporter ZIP3, Zrt- and Irt-like protein 3 - A Rabbit Polyclonal Antibody to Zinc Transporter ZIP3

Mouse, human - 11/12 amino acid residues identical

Confirmed by amino acid analysis and mass spectrometry

0.8 mg/ml

1st extracellular loop

Rat

41116161

Zinc uptake transporter, ZIP3, belongs to the SLC39 transporter family. ZIP transporters are responsible for zinc transport into the cytoplasm across cellular membranes, either influx from the extracellular space or efflux from intracellular organelles1. ZIP3 structure includes eight transmembrane (TM) domains with extracellular N- and C-termini1.Mammalian ZIP3 is encoded by the SLC39A3 gene and its expression is detected in tissues with unique requirements for Zn2+. High levels of ZIP3 are noticed in specialized hormonally-responsive secretory tissues, such as the pancreas, prostate and mammary gland2.Regulation and maintenance of proper concentration and distribution of cellular zinc nutrient by ZIP transporters are essential to the function, metabolism, growth, proliferation and survival of cells. Zinc deficiency can cause growth retardation, cognitive impairment, metabolic disorders, infertility, dysfunction of the immune system, including abnormalities in T-cells, natural killer cells and monocytes, and reduction in antibody formation1. However, excess zinc can be toxic, therefore, zinc transport plays a crucial role in regulating cellular zinc homeostasis and its levels are tightly regulated by the activity of zinc transporters.