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Prostate Specific Membrane Antigen (PSMA)

Prostate Specific Membrane Antigen (PSMA)

ArtNr	ANOG-MO-T40086A
Hersteller	Anogen
Menge	0.5mg
Kategorie	Oncology Antibodies By Cell Type Blastoma Carcinoma Immunohistochemistry Western Blot ELISA Primary Antibodies By Organ Heart & Blood Cancer Testicular & Prostate Cancer
Typ	Antibody Monoclonal
Format	Aff. Pur
Applikationen	WB, IHC, ELISA
Clon	YPSMA-1
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG2b kappa
Protein Familie	Tumor Marker
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Similar products	PSMA
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Description	Mouse monoclonal antibody to human Prostate Specific Membrane Antigen (PSMA)
Target Protein	Human Prostate Specific Membrane Antigen (PSMA)
Immunogen	Crude membrane protein preparation from pooled prostate malignant carcinoma from China.
Specificity	This antibody is reactive to PSMA expressed LNCap cell lines.
Purification	Protein G affinity purified
Species Reactivity	Human, others not tested
Cross Reactivity	Little or no cross-reactivity to benign prostate hyperplasia (BPH) or to normal prostatic tissue.
Myeloma	Sp2/0-Ag14
Background	Prostate specific membrane antigen (PSMA) is a type II trans-membrane glycoprotein found in the epithelium of prostate. It is also detectable in duodenal mucosa, renal tubules and some neuroendocrine cells. In other normal tissue, PSMA expression is not detectable. Because the expression of this membrane is elevated in malignant prostate tumour, PSMA has been used as a marker as well as a therapeutic target for prostate cancer. Elevated PSMA expression has also been identified in metastases of lymph nodes.
Formulation	Lyophilized from a solution in 0.01M PBS, pH 7.0
Reconstitution	Double distilled water is recommended to adjust the final concentration to 1.00mg/mL.
Application info	Immuno-histochemistry: This antibody was used on formalin-fixed paraffin embedded and frozen tissue sections. Indirect ELISA: This antibody is reactive to PSMA expressing LNCap cells coated ELISA plate. Western blot:The antibody, when used at 1ug/ml concentration, identified the 100KDa PSMA in LNcap cell extract.
Research Area	Oncology
Storage	Store at -20C
Reference	"PSMA mimotope isolated from phage displayed peptide library can induce PSMA specific immune response" Cell Research (1999), 9, 271-280.

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