APC / Adenomatous Polyposis Coli / FAP (Tumor Suppressor)(ALi 12-28), Biotin conjugate, 0.1mg/mL

IF (published)|IHC, frozen (published)|IP (published)|WB (published)

Adenomatous Polyposis Coli

Store at 2 to 8°C|Protect fluorescent conjugates from light

Adenomatous Polyposis Coli (APC) is a protein with many cellular functions. It is a tumor suppressor and negative regulator of Wnt signaling. APC has roles in cell adhesion and cell migration. Mutations in APC are assuciated with several diseases. The adenomatous polyposis syndromes, familial adenomatous polyposis (FAP) and Gardner's syndrome (GS), are characterized by numerous adenomatous polyps throughout the entire colon. These polyps invariably progress to colon cancer in addition to other extracolonic manifestations. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

2 years

41116161

0.05% sodium azide (CAS 26628-22-8)

PBS, 0.1% BSA, 0.05% azide

Recombinant fragment of human APC protein (around aa 1-433)

For research use only (RUO)

158932

Golgi apparatus|Plasma membrane|Nucleus

Adenomatous Polyposis Coli