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Anti-Filamin A/FLNA Antibody Picoband® (monoclonal, 3F8)

Anti-Filamin A/FLNA Antibody Picoband® (monoclonal, 3F8)

ArtNr	BOS-M00502-2
Hersteller	Boster
Menge	100 ug/vial
Quantity options	100 ug/vial 10 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug
Kategorie	Antibodies Immunohistochemistry Western Blot Immunofluorescence Cardiovascular Research Thrombosis & Hemostasis Atherosclerosis Primary Antibodies
Typ	Antibody Monoclonal
Format	Lyophilized
Applikationen	WB, IF, IHC
Clon	3F8
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG1
Sensitivity	>5000 cells
Citations	1. Gorlin JB, Henske E, Warren ST, Kunst CB, D'Urso M, Palmieri G, Hartwig JH, Bruns G, Kwiatkowski DJ (October 1993). Actin-binding protein (ABP-280) filamin gene (FLN) maps telomeric to the color vision locus (R/GCP) and centromeric to G6PD in Xq28. Genomics. 17 (2): 496–8. 2. Robertson SP, Twigg SR, Sutherland-Smith AJ, Biancalana V, Gorlin RJ, Horn D, Kenwrick SJ, Kim CA, Morava E, Newbury-Ecob R, Orstavik KH, Quarrell OW, Schwartz CE, Shears DJ, Suri M, Kendrick-Jones J, Wilkie AO (March 2003). Localized mutations in the gene encoding the cytoskeletal protein filamin A cause diverse malformations in humans. Nat Genet. 33 (4): 487–91. 3. Gräber P, Witt HT (February 1976). Relations between the electrical potential, pH gradient, proton flux and phosphorylation in the photosynthetic membrane. Biochimica et Biophysica Acta. 423 (2): 141–63.
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	T-cell surface glycoprotein CD5,Lymphocyte antigen T1/Leu-1,CD5,CD5,LEU1
Lieferbar
Manufacturer - Category	Primary Antibodies
Storage Conditions	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Observed Molecular weight	281 kDa
Clonality	Monoclonal
Application Details	Western blot, 0.25-0.5μg/ml, Human Immunohistochemistry (Paraffin-embedded Section), 2-5μg/ml, Human Immunofluorescence, 5μg/ml, Human
Gene Name	FLNA
Gene Full Name	CD5 molecule
Manufacturer - Specificity	No cross-reactivity with other proteins.
Background	Filamin A, alpha (FLNA) is a protein that in humans is encoded by the FLNA gene. It is mapped to Xq28. The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.
Immunogen	E.coli-derived human Filamin A/FLNA recombinant protein (Position: E451-Q638).
Contents	Each vial contains 4mg Trehalose, 0.9mg NaCl and 0.2mg Na2HPO4.
Purification	Immunogen affinity purified.
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Manufacturer - Research Category	Cell Adhesion, Cell Type Markers, Cytoskeleton/ECM, Hematopoietic Progenitors, Immunology, Integrins, Myeloid, Signal Transduction, Stem Cells
Protein Name	Integrin beta-2
Protein Function	May act as a receptor in regulating T-cell proliferation.
Subcellular Localization	Cell membrane; Single-pass type I membrane protein
Description	Boster Bio Anti-Filamin A/FLNA Antibody Picoband® (monoclonal, 3F8) catalog # M00502-2. Tested in IF, IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Tissue Specificity	Brain, liver, placenta, lymphocytes and erythrocytes.
Manufacturer - Cross Reactivity	No cross-reactivity with other proteins.

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BOS-M00502-2-datasheet.pdf

BOS-M00502-2-safety-datasheet.pdf