Synuclein alpha (Phospho-S129) polyclonal antibody

P37840(Human) O55042(Mouse) P37377(Rat)

The synuclein family members, including alpha-synuclein (also designated NACP for non-beta-Amyloid component) and beta-synuclein, are predominantly expressed in the brain and are speculated to be involved in synaptic regulation and neuronal plasticity. alpha-synuclein is localized to neuronal cell bodies and synapses. alpha-synuclein was first identified as a component of Alzheimer's disease amyloid plaques. Abnormal platelet function in Alzheimer's disease has been demonstrated. During megakaryocytic differentiation alpha-synuclein has been found to be upregulated, while beta-synuclein is downregulated, indicating that coordinate expression of synucleins may be important during hematopoetic cell differentiation. A mutant form of alpha-synuclein has been found in patients with early onset Parkinson's disease.

ProA affinity purified

Synuclein alpha (Phospho-S129) polyclonal antibody detects endogenous levels of Synuclein alpha protein only when phosphorylated at S129.

For research use only, not for use in diagnostic procedure.