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ATRX Antibody, Biotin conjugated

ArtNr CSB-PA002437LD01HU-50ug
Hersteller Cusabio
Menge 50 ug
Quantity options 100 ug 50 ug
Kategorie
Typ Antibody Polyclonal
Format Liquid
Applikationen ELISA
Specific against Human (Homo sapiens)
Host Rabbit
Isotype IgG
Konjugat/Tag Biotin
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias Alpha thalassemia/mental retardation syndrome X linked homolog antibody; ATP dependent helicase ATRX antibody; ATP-dependent helicase ATRX antibody; ATR2 antibody; Atrx antibody; ATRX_HUMAN antibody; DNA dependent ATPase and helicase antibody; Helicase 2; X linked antibody; MGC2094 antibody; MRXHF1 antibody; RAD54 antibody; RAD54L antibody; SFM1 antibody; SHS antibody; Transcriptional regulator ATRX antibody; X linked helicase II antibody; X linked nuclear protein antibody; X-linked helicase II antibody; X-linked nuclear protein antibody; XH2 antibody; XNP antibody; Znf HX antibody; Znf-HX antibody
Similar products ATRX, Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX), RAD54L XH2
Lieferbar
Manufacturer - Type
Polyclonal Antibody
Manufacturer - Targets
ATRX
Storage Conditions
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Manufacturer - Alias
Alpha thalassemia/mental retardation syndrome X linked homolog antibody; ATP dependent helicase ATRX antibody; ATP-dependent helicase ATRX antibody; ATR2 antibody; Atrx antibody; ATRX_HUMAN antibody; DNA dependent ATPase and helicase antibody; Helicase 2; X linked antibody; MGC2094 antibody; MRXHF1 antibody; RAD54 antibody; RAD54L antibody; SFM1 antibody; SHS antibody; Transcriptional regulator ATRX antibody; X linked helicase II antibody; X linked nuclear protein antibody; X-linked helicase II antibody; X-linked nuclear protein antibody; XH2 antibody; XNP antibody; Znf HX antibody; Znf-HX antibody
Immunogen Species
Human
Immunogen
Recombinant Human Transcriptional regulator ATRX protein (2161-2443AA)
Background
Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. Its heterochromatin targeting is proposed to involve a combinatorial readout of histone H3 modifications (specifically methylation states of H3K9 and H3K4) and association with CBX5. Involved in maintaining telomere structural integrity in embryonic stem cells which probably implies recruitment of CBX5 to telomers. Reports on the involvement in transcriptional regulation of telomeric repeat-containing RNA (TERRA) are conflicting, according to a report, it is not sufficient to decrease chromatin condensation at telomers nor to increase expression of telomeric RNA in fibroblasts (PubMed:24500201). May be involved in telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines. Acts as negative regulator of chromatin incorporation of transcriptionally repressive histone H2AFY, particularily at telomeres and the alpha-globin cluster in erythroleukemic cells. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, required for the chromatin occupancy of SMC1 and CTCTF within the H19 imprinting control region (ICR) and involved in esatblishment of histone tails modifications in the ICR. May be involved in brain development and facial morphogenesis. Binds to zinc-finger coding genes with atypical chromatin signatures and regulates its H3K9me3 levels. Forms a complex with ZNF274, TRIM28 and SETDB1 to facilitate the deposition and maintenance of H3K9me3 at the 3' exons of zinc-finger genes (PubMed:27029610).
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method
>95%, Protein G purified
General Research Areas
Epigenetics and Nuclear Signaling
Initial Research Areas
Epigenetics and Nuclear Signaling
Antigen Species
Human
Antigen
Recombinant Human Transcriptional regulator ATRX protein (2161-2443AA)
Clonality
Polyclonal

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 50 ug
Lieferbar: In stock
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