INSIG1 Antibody, HRP conjugated

Polyclonal Antibody

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Human

Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase, AMFR/gp78. May play a role in growth and differentiation of tissues involved in metabolic control. May play a regulatory role during G0/G1 transition of cell growth.

>95%, Protein G purified

Cardiovascular

Recombinant Human Insulin-induced gene 1 protein (1-87AA)