LEPR Antibody

LEPR

CD 295 antibody; CD295 antibody; CD295 antigen antibody; Db antibody; Fa antibody; HuB219 antibody; LEP R antibody; LEP-R antibody; LEPR antibody; LEPR_HUMAN antibody; LEPRD antibody; Leptin receptor antibody; Leptin receptor fatty antibody; Leptin receptor gene related protein antibody; Leptin receptor precursor antibody; Leptin receptor precursor antibody; OB R gene related protein antibody; OB receptor antibody; OB-R antibody; OB-RGRP antibody; obl antibody; Obr antibody

Recombinant Human Leptin receptor protein (874-1075AA)

Receptor for hormone LEP/leptin (Probable) (PubMed:22405007). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones (By similarity) (PubMed:9537324). In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity (PubMed:25060689, PubMed:12504075, PubMed:8805376). Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis. Involved in the regulation of counter-regulatory response to hypoglycemia by inhibiting neurons of the parabrachial nucleus. Has a specific effect on T lymphocyte responses, differentially regulating the proliferation of naive and memory T -ells. Leptin increases Th1 and suppresses Th2 cytokine production (By similarity).

>95%, Protein G purified

Signal Transduction

Recombinant Human Leptin receptor protein (874-1075AA)