STT3B Antibody

Polyclonal Antibody

STT3B

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B antibody, Homolog of yeast STT3 antibody, Oligosaccharyl transferase subunit STT3B antibody, SIMP antibody, source of immunodominant MHC associated peptides antibody, Source of immunodominant MHC-associated peptides homolog antibody, STT3 subunit of the oligosaccharyltransferase complex homolog B (S. cerevisiae) antibody, STT3 subunit of the oligosaccharyltransferase complex homolog B antibody, STT3-B antibody, Stt3b antibody, STT3B_HUMAN antibody

Recombinant Human Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B protein (682-809AA)

Catalytic subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). STT3B is present in a small subset of OST complexes and mediates both cotranslational and post-translational N-glycosylation of target proteins: STT3B-containing complexes are required for efficient post-translational glycosylation and while they are less competent than STT3A-containing complexes for cotranslational glycosylation, they have the ability to mediate glycosylation of some nascent sites that are not accessible for STT3A. STT3B-containing complexes also act post-translationally and mediate modification of skipped glycosylation sites in unfolded proteins. Plays a role in ER-associated degradation (ERAD) pathway that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins by mediating N-glycosylation of unfolded proteins, which are then recognized by the ERAD pathway and targeted for degradation. Mediates glycosylation of the disease variant AMYL-TTR 'Asp-38' of TTR at 'Asn-118', leading to its degradation.

>95%, Protein G purified

Signal Transduction

Recombinant Human Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B protein (682-809AA)