EXOSC5 Antibody

EXOSC5

Chronic myelogenous leukemia tumor antigen 28 antibody; CML28 antibody; EXOS5_HUMAN antibody; EXOSC 5 antibody; Exosc5 antibody; Exosome complex component rrp46 antibody; exosome complex exonuclease RRP46 antibody; Exosome component 5 antibody; exosome component Rrp46 antibody; hRrp46p antibody; p12B antibody; Ribosomal RNA processing protein 46 antibody; Ribosomal RNA processing protein 46, S. cerevisiae, homolog of antibody; Ribosomal RNA-processing protein 46 antibody; RRP41B antibody; RRP46 antibody; Rrp46p antibody

Recombinant Human Exosome complex component RRP46 protein (1-235AA)

Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.

>95%, Protein G purified

Epigenetics and Nuclear Signaling

Recombinant Human Exosome complex component RRP46 protein (1-235AA)