RNF41 Antibody

Polyclonal Antibody

RNF41

4930511A05Rik antibody, 4933415P08Rik antibody, E3 ubiquitin protein ligase NRDP1 antibody, E3 ubiquitin-protein ligase NRDP1 antibody, Fetal Liver RING finger protein antibody, FLRF antibody, MGC45228 antibody, Neuregulin receptor degradation protein 1 antibody, NRDP1 antibody, RING finger protein 41 antibody, rnf41 antibody, RNF41_HUMAN antibody, SBBI03 antibody

Recombinant Human E3 ubiquitin-protein ligase NRDP1 protein (1-317AA)

Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus (By similarity). Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PARK2 modifier that accelerates its degradation, resulting in a reduction of PARK2 activity, influencing the balance of intracellular redox state. The RNF41-PARK2 pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control (PubMed:24949970).

Antigen Affinity Purified

Cell Biology

Recombinant Human E3 ubiquitin-protein ligase NRDP1 protein (1-317AA)