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ITGAV Recombinant Monoclonal Antibody

ITGAV Recombinant Monoclonal Antibody

ArtNr	CSB-RA279866A0HU-100ul
Hersteller	Cusabio
Menge	100 ul
Quantity options	100 ul 50 ul
Kategorie	Oncology Neuroscience Neural Adhesion Molecules Infectious Diseases Viral Infections Coronavirus (COVID-19) Antibodies By Cell Type Carcinoma Cell Biology Immunohistochemistry Western Blot ELISA Cell Stainings ECM Primary Antibodies
Typ	Antibody Monoclonal
Format	Liquid
Applikationen	WB, IHC, ELISA
Clon	5G3
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Integrin alpha-V (Vitronectin receptor) (Vitronectin receptor subunit alpha) (CD antigen CD51) [Cleaved into: Integrin alpha-V heavy chain, Integrin alpha-V light chain], ITGAV, MSK8 VNRA VTNR
Similar products	ITGAV, Integrin alpha-V (Vitronectin receptor) (Vitronectin receptor subunit alpha) (CD antigen CD51) [Cleaved into: Integrin alpha-V heavy chain, Integrin alpha-V light chain], MSK8 VNRA VTNR
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Manufacturer - Type	Recombinant Antibody
Manufacturer - Applications	ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:200
Manufacturer - Isotype	Rabbit IgG
Manufacturer - Targets	ITGAV
Storage Conditions	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Immunogen	A synthesized peptide derived from human Integrin alpha V
Dilution	WB:1:500-1:5000, IHC:1:50-1:200
Background	The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415). ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (PubMed:18441324). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:19578119). ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGAV:ITGB3 and ITGAV:ITGB6 act as a receptor for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881).
Buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method	Affinity-chromatography
General Research Areas	Cancer; Cardiovascular; Microbiology; Signal transduction; Stem cells
Modified	Cancer; Cardiovascular; Microbiology; Signal transduction; Stem cells
Antigen Species	Human
Antigen	A synthesized peptide derived from human Integrin alpha V
Clonality	Monoclonal

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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CSB-RA279866A0HU-100ul-datasheet.pdf

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Menge: 100 ul

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Lieferung vsl. bis 02.10.2025

Express-Lieferung: 6 Tage sparen

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