PTGS2 Recombinant Monoclonal Antibody

ELISA, WB, IF; Recommended dilution: WB:1:500-1:5000, IF:1:20-1:200

PTGS2

A synthesized peptide derived from human COX2

Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.

Affinity-chromatography

Cancer; Cardiovascular; Metabolism; Signal transduction

A synthesized peptide derived from human COX2