WT1 Recombinant Monoclonal Antibody

ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:200

WT1

A synthesized peptide derived from human Wilms Tumor Protein

Transcription factor that plays an important role in cellular development and cell survival (PubMed:7862533). Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3' (PubMed:7862533, PubMed:17716689, PubMed:25258363). Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors (PubMed:15520190). Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing (PubMed:16934801). Isoform 1 has lower affinity for DNA, and can bind RNA (PubMed:19123921).

Affinity-chromatography

Epigenetics and Nuclear Signaling; Cancer; Developmental biology; Tags & Cell Markers

A synthesized peptide derived from human Wilms Tumor Protein