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Phospho-SMAD3 (Ser425) Monoclonal Antibody

Phospho-SMAD3 (Ser425) Monoclonal Antibody

ArtNr	E-AB-51043-20
Hersteller	Elabscience
Menge	20 uL
Quantity options	120 uL 20 uL 200 uL 60 uL
Kategorie	Oncology Antibodies Immunohistochemistry Primary Antibodies By Organ Colorectal Cancer
Typ	Antibody
Applikationen	IHC-P
Clon	4C5
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Mouse
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	https://www.karger.com/Article/Abstract/452571
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	DKFZP586N0721, DKFZp686J10186, hMAD 3, hMAD-3, hSMAD3, HSPC193, HST17436, JV15 2, JV15-2, JV152, LDS1C, LDS3, MAD (mothers against decapentaplegic Drosophila) homolog 3, MAD homolog 3, Mad homolog JV15 2, Mad protein homolog, MAD, mothers against decapentaplegic homolog 3, Mad3, MADH 3, MADH3, MGC60396, Mothers against decapentaplegic homolog 3, Mothers against DPP homolog 3, SMA and MAD related protein 3, SMAD 3, SMAD, SMAD family member 3, SMAD, mothers against DPP homolog 3, Smad3, SMAD3
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Category	Primary Antibodies / Acetyl/Phospho/Methyl Antibodies
Shipping Temperature	The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions	Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Research Areas	Cancer, Epigenetics and Nuclear Signaling, Metabolism, Signal Transduction, Stem Cells
Background	Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Concentration	1 mg/mL
Buffer	PBS with 0.02% sodium azide and 50% glycerol pH 7.4.
Purification Method	Protein A purification
Recommended Dilution	IHC 1:50-300
Santa Cruz #	sc-8332
Abbreviation	Phospho-SMAD3 (Ser425)
Clonality	Monoclonal
Immunogen	Synthetic Peptide of Phospho-Smad3 (Ser425)

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