Perforin Polyclonal Antibody

Primary Antibodies

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

70kDa

The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein.

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

WB 1:500-1:2000; IHC 1:50-1:200; IF 1:50-1:200

Polyclonal