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Bulk Anti-Human CD11a (38) Antibody Europäischer Partner

ArtNr ICH1006-1MG
Hersteller IchorBio
Menge 1 mg
Quantity options 100 mg 1 mg 25 mg 50 mg 5 mg
Kategorie
Typ Antibody Monoclonal
Format Liquid
Applikationen WB, FC, IF, IP, IHC
Clon 38
Specific against Human (Homo sapiens)
Host Mouse
Isotype IgG2a
Purity >95% by SDS-PAGE and HPLC
ECLASS 10.1 42030590
ECLASS 11.0 42030590
UNSPSC 12352203
Alias LFA-1 alpha,LFA-1A,Integrin alpha-L,ITGAL
Versandbedingung Gekühlt
Lieferbar
Manufacturer - Type
Low Endotoxin, anti-human
Manufacturer - Applications
Flow Cytometry, Western Blot, IHC (Frozen), Immunofluorescence, Immunoprecipitation
Manufacturer - Category
Low Endotoxin, anti-human, monoclonal antibody
Manufacturer - Targets
CD11a
Shipping Temperature
Blue ice
Storage Conditions
anti-CD11a In Vivo Antibody - Low Endotoxin (38) is stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
Aggregation
Aggregation level ≤ 5%
Formulation
0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added.
Antigen Distribution
The CD11a antigen is present on most leukocytes and plays a vital role in cellular immune responses which require adhesion. Lymphocyte activation via the T-cell antigen receptor (TCR) up-regulates LFA-1 function. The absence of LFA-1A or B may induce the disease state known as leukocyte adhesion deficiency (LAD). Tumor cells which do not express LFA-1 may have avoided cellular immune-responses such as those carried out by natural killer cells (NK).
Application Notes
Each investigator should determine their own optimal working dilution for specific applications.
Background
Anti-CD11a may be used to study a variety of biological phenomena related to the function of cell adhesion molecules. This antibody may be used to study transplantation rejections and to assist in characterizing lymphomas and leukemias.
Concentration
1.0 - 5.0 mg/ml
Endotoxin
≤ 1.0 EU/mg as determined by the LAL method
Manufacturer - Specificity
Anti-CD11a In Vivo Antibody - Low Endotoxin (38) recognizes Human CD11a. Anti-Human CD11a (Anti-LFA-1a) recognizes the (Mr 175 kDa) a chain of the leukocyte function associated antigen-1 (LFA-1). The leukocyte integrin LFA-1 is a member of a family of heterodimeric receptors that mediate divalent cation-dependent cellular adhesion reactions. LFA-1A binds to domain 1 of an intercellular adhesion molecule (ICAM) on target tissues.
Purification method
This monoclonal antibody was purified using Protein A
Use
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
Immunogen
Unknown
Antibodies against the same target (Cat No.)
Anti-CD11a In Vivo Antibody - Low Endotoxin [FD441.8] (ICH1047), Anti-CD11a In Vivo Antibody - Low Endotoxin [I21/7] (ICH1048)
Isotype Control
Mouse IgG2a In Vivo Isotype Control - Low Endotoxin [C1.18.4] (ICH2245)
Buffer

Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.

Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 1 mg
Lieferbar: In stock
lieferbar

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