Anti-Mouse IL-12 In Vivo Antibody - Low Endotoxin (C17.8)

anti-IL-12 In Vivo Antibody - Low Endotoxin (C17.8) is stable when stored at 2-8C. For long term storage aseptically aliquot in working volumes without diluting and store at -80C. Avoid Repeated Freeze Thaw Cycles.

0.01 M phosphate buffered saline (PBS) pH 7.0, 150 mM NaCl with no carrier protein, potassium or preservatives added.

Interleukin 12 (IL-12, NK cell stimulatory factor, cytotoxic lymphocyte maturation factor) is a heterodimeric cytokine that is naturally produced by dendritic cells , macrophages and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is involved in the differentiation of naive T cells into Th1 cells, which is important in resistance against pathogens. It is known as a T cell stimulating factor, which can stimulate the growth and function of T cells. It stimulates the production of IFN-gamma and TNF-A from T and natural killer (NK) cells, and reduces IL-4 mediated suppression of IFN-gamma. IL-12 also has anti-angiogenic activity, which can block the formation of new blood vessels. IL-12 binds to the IL-12 receptor and upon binding, IL-12R-beta2 becomes tyrosine phosphorylated and provides binding sites for kinases, Tyk2 and Jak2. These are important in activating critical transcription factor proteins such as STAT4 which are implicated in IL-12 signaling in T cells and NK cells. IL-12 contributes to the antimycobacterial immune response by enhancing production of interferon-gamma, facilitating development of Th1 cells and augmenting cytotoxicity of antigen-specific T cells and natural killer cells.

<= 1.0 EU/mg as determined by the LAL method

Products are for research use only. Not for use in diagnostic or therapeutic procedures.