Anti-Mouse TNF Alpha (TN3-19.12) In Vivo Antibody - Low Endotoxin

Immunoprecipitation, Western Blot, Functional Assays, Flow Cytometry, Blocking

Armenian Hamster IgG

Blue ice

Aggregation level ≤ 5%

Activated monocytes, neutrophils, macrophages, T cells, B cells, NK cells, LAK cells

The tumor necrosis factor (TNF-alpha) is a multifaceted polypeptide cytokine known as a mediator of inflammation and immunity. It may mediate some of the significant changes in cellular homeostasis which accompany the invasion of the mammalian host by viruses, bacteria, and parasites. TNF-alpha is an acute phase protein which initiates a cascade of cytokines and increases vascular permeability, thereby recruiting macrophage and neutrophils to a site of infection. TNF-alpha secreted by the macrophage causes blood clotting which serves to contain the infection. TNF-alpha has been detected in synovial fluid of patients with rheumatoid arthritis. Clone TN3-19.12 antibody can neutralize the bioactivity of natural or recombinant TNF-alpha

≤ 1.0 EU/mg as determined by the LAL method

This monoclonal antibody was purified using Protein A

Recombinant mouse TNFalpha

Anti-TNF alpha In Vivo Antibody - Low Endotoxin [MP6-XT22] (ICH1127)

ICH3001-100ml; ICH3002-100ml; ICH3003-100ml