Anti-Mouse TCR Beta (H57-597) Antibody In Vivo Antibody - Low Endotoxin

Flow Cytometry, Costimulatory, Depletion, Immunoprecipitation, IHC (Frozen), IHC (Paraffin), CODEX

Armenian Hamster IgG

Blue ice

Aggregation level ≤ 5%

TCRβ is expressed on αβ thymocytes, peripheral T cells, and NKT cells.

TCRβ antibody, clone H57-597, recognizes the beta chain of the T cell receptor (TCRβ), expressed on αβ thymocytes and T lymphocytes, as well as natural killer T (NKT) cells. TCRβ is a transmembrane protein that consists of an amino-terminal variable region, a constant region, and a stalk segment covalently linked to the TCR alpha chain (TCRα) via a disulfide bond. TCRα/β does not contain signaling domains and is instead noncovalently associated with the CD3 complex (TCR-CD3), essential for TCR signaling. TCRα/β recognizes antigens bound to major histocompatibility complex (MHC) molecules, resulting in phosphorylation of CD3 ITAMs and subsequent T cell activation, proliferation, and survival.

<1.0 EU/mg as determined by the LAL method

This monoclonal antibody was purified using Protein A

Affinity purified TCR from mouse DO-11.10 cells

ICH3001-100ml; ICH3002-100ml; ICH3003-100ml