Anti-Mouse CD105 (MJ7/18) In Vivo Antibody- Low Endotoxin

Agonist, Cell Separation, ELISA, Flow Cytometry, Immunofluorescence, IF Microscopy, Immunohistochemistry, IHC FF, Immunoprecipitation, LCI, Western Blot

Rat IgG2a Kappa

Blue ice

Aggregation level ≤ 5%

CD105 is alternatively spliced, resulting in both long (L-endoglin) and short (S-endoglin) forms. The predominant isoform, L-endoglin, promotes the proliferation and migration of endothelial cells via enhanced ALK1-Smad1/5 signaling and is the presumed isoform when not specified in the literature. In contrast, S-endoglin enhances ALK5-Smad2/3 signaling. Endoglin has specific receptor-ligand interactions between type I and type II TGF-β superfamily receptors when binding TGF-β superfamily ligands. Mouse CD105 has three separate regions of similarity to TGF-β receptor III but does not contain the RGD tripeptide found in human CD105.

CD105 (endoglin) is a TGF-β superfamily co-receptor that promotes angiogenesis, is involved in endothelial integrin-mediated mural cell and leukocyte adhesion, antagonizes TGF-β mediated ERK activation, is essential to the immune response of macrophages, regulates trophoblast differentiation and invasion during pregnancy, promotes T-cell proliferation, and regulates differentiation and collagen expression in myofibroblasts

<1.0 EU/mg as determined by the LAL method

This monoclonal antibody was purified using Protein G

MJ7/18 was produced by immunizing rats with inflamed mouse skin and selecting for reactivity with endothelial cells. MJ7/18 predominantly stains vascular endothelial cells and is a marker of mouse endothelium

ICH3001-100ml; ICH3002-100ml; ICH3003-100ml