mouse anti-HSP70, cross reactive with E.coli DNAK

blue ice

Molecular cell biology

This antibody is cross reactive with human HSP70 and E.coli DNAK. Mycobaterial HSP70 is the prokaryotic analogue of eukaryotic Hsp70 and is an effective subunit vaccine against bovine paratuberculosis. HSP70 belongs to a group of heat shock proteins that assist in the assembly, folding and translocation of other proteins. In addition, they protect the cell against heat injury or other forms of stress. All cells, prokaryotic and eukaryotic, are able to respond to different cellular stresses by synthesizing these proteins. Heat shock proteins are highly conserved, ubiquitously distributed, and involved in important aspects of viral and bacterial infections, autoimmune diseases, and in cancer immunity.

Solution