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Anti-Human Beta-Defensin 4/2 - 100 µg

Anti-Human Beta-Defensin 4/2 - 100 µg

ArtNr	LEIN-B377-100ug
Hersteller	Leinco Technologies
Menge	100 ug
Quantity options	100 ug 25 ug
Kategorie	Antibodies Immunohistochemistry Western Blot Primary Antibodies
Typ	Antibody Primary
Applikationen	WB, IHC
Specific against	Human (Homo sapiens)
Host	Caprine
NCBI	1673
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Applications	IHC FFPE, WB
Manufacturer - Category	Polyclonal Antibodies>Growth Factors & Cytokines
Manufacturer - Targets	Beta-Defensin 4/2
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	The lyophilized antigen affinity purified polyclonal antibody can be stored desiccated at -20°C to -70°C for twelve months from date of receipt. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. No detectable loss of activity was observed after six months.
Product Description	Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The alpha-defensins are distinguished from the beta-defensins by the pairing of their three disulfide bonds. To date, four human beta-defensins have been identified; BD-1, BD-2, BD-3 and BD-4. In addition to their direct antimicrobial activities, they are chemoattractant towards immature dendritic cells and memory T cells. The beta-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence and, in the case of BD-1, a propeptide region. Beta-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. Human, rabbit and guinea-pig beta-defensins, as well as human beta-defensin-2 (hBD2), induce the activation and degranulation of mast cells, resulting in the release of histamine and prostaglandin D2.
Background	Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The alpha-defensins are distinguished from the beta-defensins by the pairing of their three disulfide bonds. To date, four human beta-defensins have been identified; BD-1, BD-2, BD-3 and BD-4. In addition to their direct antimicrobial activities, they are chemoattractant towards immature dendritic cells and memory T cells. The beta-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence and, in the case of BD-1, a propeptide region. Beta-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. Human, rabbit and guinea-pig beta-defensins, as well as human beta-defensin-2 (hBD2), induce the activation and degranulation of mast cells, resulting in the release of histamine and prostaglandin D2.
Other Applications Reported In Literature	IHC (NBF/Par.): This antibody should give satisfactory staining results when used at a concentration of 5-15 µg/ml. The recommended secondary antibody for IHC is PN:G505. For chromogenic detection with high signal and low background use PN:D100 or PN:K107.
PubMed	Beta-Defensin 4/2
Manufacturer - Specificity	Goat Anti-Human Beta-Defensin-2 (BD-2) recognizes Human BD-2. This antigen affinity purified polyclonal antibody was purified using a proprietary chromatographic technique that includes covalently immobilizing the antigen proteins or peptides to agarose based beads. This purification method enhances specificity, reduces nonspecific binding of extraneous IgG and provides you with the most reliable reagent available for your early discovery research.
RRID	AB_2828177
Formulation	This antigen affinity purified polyclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 containing 5.0% w/v trehalose with no calcium, magnesium, or preservatives present.
Antigen Distribution	Beta-defensins are expressed on some leukocytes and at epithelial surfaces.
Immunogen	E. coli-Derived Recombinant Human BD-2 (Amino Acid 24 - 64)
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	Polyclonal Antibody, Beta-Defensin-2, Skin-antimicrobial peptide 1 [SAP1], BD-2, Human BD-2, Anti-Human Beta-Defensin-2, BD-2, betaDefensin 2, beta-Defensin 2, DEFB2, DEFB-2, DEFB2DEFB102, DEFB4A, DEFB4B, DEFB4beta-defensin 4A, Defensin beta 2Skin-antimicrobial peptide 1, defensin beta 4, defensin beta 4A, HBD-2, SAP-1, SAP1BD-2

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LEIN-B377-100ug-safety-datasheet.pdf