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Anti-Human Bcl-2 (NT) - 0.1 mg

Anti-Human Bcl-2 (NT) - 0.1 mg

ArtNr	LEIN-B446-0.1mg
Hersteller	Leinco Technologies
Menge	0.1 mg
Quantity options	0.1 mg 20 ug
Kategorie	Antibodies Immunohistochemistry Western Blot Primary Antibodies
Typ	Antibody Primary
Applikationen	WB, IHC
Specific against	Human (Homo sapiens)
Host	Rabbit
Citations	1. Lockshin, RA. et al. (2000) Cell Death Differ. 7:2-7. 2. Cory, S. et al. (2003) Oncogene 22:8590-607. 3. Heiser, D. et al. (2004) Exp. Geron. 39:1125-35. 4. Hockenbery, D. et al. (1990) Nature 348:334-6.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Applications	IHC FFPE, WB
Manufacturer - Category	Primary Monoclonal Antibodies>Apoptosis & Cell Biology
Manufacturer - Targets	Bcl-2
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Product Description	Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer.2 Bcl-2 is the founding member of a family of over 20 proteins that are critical regulators of apoptosis.2, 3 These can be divided into two classes: those that inhibit apoptosis and those that promote cell death. Bcl-2 is an inner mitochondrial membrane protein that inhibits apoptosis.4 It is thought to act by interacting with pro-apoptotic Bcl-2 family members such as Bak and Bad.5 Overexpression of Bcl-2 has been linked to human cancers such as B-cell lymphoma and prostate cancer.4, 6
Background	Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer.² Bcl-2 is the founding member of a family of over 20 proteins that are critical regulators of apoptosis.^{2, 3} These can be divided into two classes: those that inhibit apoptosis and those that promote cell death. Bcl-2 is an inner mitochondrial membrane protein that inhibits apoptosis.⁴ It is thought to act by interacting with pro-apoptotic Bcl-2 family members such as Bak and Bad.⁵ Overexpression of Bcl-2 has been linked to human cancers such as B-cell lymphoma and prostate cancer.^{4, 6}
PubMed	Bcl-2
Manufacturer - Specificity	Rabbit Anti-Human Bcl-2 recognizes an epitope near the N-terminus of human and mouse Bcl-2. This polyclonal antibody was purified using affinity chromatography.
RRID	AB_2828204
Concentration	0.5 mg/ml
Formulation	This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Immunogen	PN:B472
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	Bcl-2 Antibody, Bcl-2, PPP1R50, Apoptosis regulator Bcl-2

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LEIN-B446-0.1mg-safety-datasheet.pdf