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Anti-Human Bcl-xL - 0.1 mg

Anti-Human Bcl-xL - 0.1 mg

ArtNr	LEIN-B450-0.1mg
Hersteller	Leinco Technologies
Menge	0.1 mg
Quantity options	0.1 mg 20 ug
Kategorie	Antibodies Western Blot Primary Antibodies
Typ	Antibody Primary
Applikationen	WB
Specific against	Human (Homo sapiens)
Host	Rabbit
Citations	1. Lockshin, RA. et al. (2000) Cell Death Differ. 7:2-7. 2. Cory, S. et al. (2003) Oncogene 22:8590-607. 3. Heiser, D. et al. (2004) Exp. Geron. 39:1125-35. 4. Gonzalez-Garcia, M. et al. (1994) Development 120:3033-42.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Category	Primary Monoclonal Antibodies>Apoptosis & Cell Biology
Manufacturer - Targets	Bcl-xL
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Product Description	Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer.1 Bcl-xL is a member of the Bcl-2 family of proteins that are critical regulators of apoptosis.2, 3 These can be divided into two classes: those that inhibit apoptosis and those that promote cell death. Bcl-xL is an anti-apoptotic mitochondrial protein related to Bcl-w and the major transcript of the bcl-x gene.4 Its high expression in tumors is correlated with advanced disease and poor prognosis.5 Bcl-xL expression level increases in response to several stimuli such as ionizing radiation and treatment with chemotherapeutic agents.6, 7
Background	Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer.¹ Bcl-xL is a member of the Bcl-2 family of proteins that are critical regulators of apoptosis.^{2, 3} These can be divided into two classes: those that inhibit apoptosis and those that promote cell death. Bcl-xL is an anti-apoptotic mitochondrial protein related to Bcl-w and the major transcript of the bcl-x gene.⁴ Its high expression in tumors is correlated with advanced disease and poor prognosis.⁵ Bcl-xL expression level increases in response to several stimuli such as ionizing radiation and treatment with chemotherapeutic agents.^{6, 7}
PubMed	Bcl-xL
Manufacturer - Specificity	Rabbit Anti-Human Basal Cell Lymphoma-Extra Large (Bcl-xL) recognizes Human Bcl-xL. This polyclonal antibody was purified using affinity chromatography.
RRID	AB_2828208
Concentration	0.5 mg/ml
Formulation	This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Immunogen	Purified Recombinant Human Bcl-xL (> 98%)
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	Polyclonal Antibody, Basal Cell Lymphoma-Extra Large, Bcl-xL, Human, Anti-Human Bcl-xL, Bcl-xL Antibody, BCLX, BCL2L, BCLXL, BCLXS, Bcl-X, bcl-xL, bcl-xS, PPP1R52, BCL-XL/S, BCLX, Bcl-2-like protein 1, Apoptosis regulator Bcl-X, Bcl2-L-1

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LEIN-B450-0.1mg-safety-datasheet.pdf