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Anti-Human CCR3 (CT) - 0.1 mg

ArtNr LEIN-C1304-0.1mg
Hersteller Leinco Technologies
Menge 0.1 mg
Quantity options 0.1 mg 20 ug
Kategorie
Typ Antibody Primary
Applikationen WB, IHC, ICC
Specific against Human (Homo sapiens)
Host Rabbit
Citations 1. Feng, Y. et al. (1996) Science 272:872
2. Deng, H. et al. (1996) Nature 381:661
3. Choe, H. et al. (1996) Cell 85:1135
4. He, J. et al. (1997) Nature 385:645
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Versandbedingung Raumtemperatur
Lieferbar
Manufacturer - Applications
ICC, IHC FFPE, WB
Manufacturer - Category
Polyclonal Antibodies>Growth Factors & Cytokines
Manufacturer - Targets
CCR3
Country of Origin
USA
Shipping Temperature
Next Day Ambient
Storage Conditions
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Product Description
Human immunodeficiency virus (HIV) and related virus require coreceptors to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b, CCR8, GPR15, STRL33, and CX3CR1 in the chemokine receptor family were recently identified as HIV coreceptors. CCR5, CXCR4 and CCR3 are the principal receptors for HIV fusion and entry of target cells. CCR3 facilitates infection by a subset of virus. CCR3 and CCR5 promote efficient infection of microglia, the major target cells in the CNS.3, 4 High levels of CCR3 and CXCR4 expression were found on the neurons from both the central and peripheral nervous systems. The CCR3 ligand, eotaxin, and an anti-CCR3 antibody inhibited HIV infection of microglia. These results indicate CCR3 plays an important role in HIV infection of CNS.
Background
Human immunodeficiency virus (HIV) and related virus require coreceptors to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b, CCR8, GPR15, STRL33, and CX3CR1 in the chemokine receptor family were recently identified as HIV coreceptors. CCR5, CXCR4 and CCR3 are the principal receptors for HIV fusion and entry of target cells. CCR3 facilitates infection by a subset of virus. CCR3 and CCR5 promote efficient infection of microglia, the major target cells in the CNS.3, 4 High levels of CCR3 and CXCR4 expression were found on the neurons from both the central and peripheral nervous systems. The CCR3 ligand, eotaxin, and an anti-CCR3 antibody inhibited HIV infection of microglia. These results indicate CCR3 plays an important role in HIV infection of CNS.
PubMed
CCR3
Manufacturer - Specificity
Rabbit Anti-Human CCR3 recognizes an epitope near the C-terminus of Human, Mouse and Rat CCR3. This polyclonal antibody was purified using affinity chromatography.
RRID
AB_2828411
Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Immunogen
Purified Recombinant Human CCR3 (NP_847899)
Additional Information
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords
Polyclonal Antibody, CC Chemokine Receptor-3, Eosinophil Eotaxin Receptor, CC Chemokine Receptor 3, CCR3, Human, Anti-Human CC Chemokine Receptor 3 (CT) (CCR3), CCR3 Antibody, CKR3, CD193, CMKBR3, CC-CKR-3, C-C chemokine receptor type 3, Eosinophil eotaxin receptor, C-C CKR-3

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 0.1 mg
Lieferbar: In stock
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