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Anti-Mouse CXCL10 (Clone 134013) - 100 µg

Anti-Mouse CXCL10 (Clone 134013) - 100 µg

ArtNr	LEIN-C1423-100ug
Hersteller	Leinco Technologies
Menge	100 ug
Quantity options	100 ug 25 ug 500 ug
Kategorie	Neuroscience Neuroinflammation Antibodies Western Blot ELISA Primary Antibodies Immunostaining
Typ	Antibody Monoclonal
Applikationen	WB, ELISA
Clon	134013
Specific against	Mouse (Murine, Mus musculus)
Host	Rat
Citations	1. Luster, AD. et al.(1985) Nature 315: 672 2. Dufour, JH. et al.(2002) J. Immunol. 168 3. Angiolillo, AL. et al.(1995) J. Exp. Med. 182: 155 4. Kaneko, S. et al.(2008) Nephron Exp. Nephrol. 109:(1):c29-38
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Applications	ELISA Cap, N, WB
Manufacturer - Category	Primary Monoclonal Antibodies>Growth Factors and Cytokines
Manufacturer - Targets	CXCL10
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	The lyophilized antibody can be stored desiccated at -20°C to -70°C for up to twelve months. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles. No detectable loss of activity was observed after six months.
Product Description	Chemokine (C-X-C motif) ligand 10 (CXCL10) or IP-10 is a small cytokine belonging to the CXC chemokine family. CXCL10 is secreted by several cell types in response to IFN-γ. These cell types include monocytes, endothelial cells and fibroblasts.1 CXCL10 has been attributed to several roles, such as chemoattraction for monocytes/macrophages, T cells, NK cells, and dendritic cells, promotion of T cell adhesion to endothelial cells, antitumor activity, and inhibition of bone marrow colony formation and angiogenesis.2, 3 CXCL10 plays a role in the regulation of tubular cell proliferation following renal ischemia-reperfusion injury.4
Background	Chemokine (C-X-C motif) ligand 10 (CXCL10) or IP-10 is a small cytokine belonging to the CXC chemokine family. CXCL10 is secreted by several cell types in response to IFN-γ. These cell types include monocytes, endothelial cells and fibroblasts.¹ CXCL10 has been attributed to several roles, such as chemoattraction for monocytes/macrophages, T cells, NK cells, and dendritic cells, promotion of T cell adhesion to endothelial cells, antitumor activity, and inhibition of bone marrow colony formation and angiogenesis.^{2, 3} CXCL10 plays a role in the regulation of tubular cell proliferation following renal ischemia-reperfusion injury.⁴
Other Applications Reported In Literature	Neutralization: This antibody is useful for neutralization of Mouse CXCL10 bioactivity. The antibody dose required to neutralize 50% (ND₅₀) of the biological activity of Mouse CXCL10 (at 0.5 ng/ml) is 10-40 µg/ml.
PubMed	CXCL10
Manufacturer - Research Area	Chemokine
Manufacturer - Specificity	Rat Anti-Mouse Chemokine (C-X-C Motif) Ligand 10 (CXCL10) (Clone 134013) recognizes an epitope on Mouse CXCL10. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
RRID	AB_2828483
Formulation	This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present.
Endotoxin Level	< 0.1 EU/µg as determined by the LAL method
Immunogen	E. coli-Derived Recombinant Mouse CXCL10
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	Monoclonal Antibody, Chemokine (C-X-C Motif) Ligand 10 , C7, IFI10, INP10, IP-10, SCYB10, Crg-2, GIP-10, Mob-1, 134013, CXCL10, Mouse CXCL10, Anti-Mouse CXCL10, Clone 134013, C7, chemokine (C-X-C motif) ligand 10, CRG2, CRG-2, CXCL10, gIP-10, IFI10, INP10, IP-10, mob-1, SCYB10

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LEIN-C1423-100ug-safety-datasheet.pdf