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Anti-Human CD62L - Purified - 500 µg

Anti-Human CD62L - Purified - 500 µg

ArtNr	LEIN-C2140-500ug
Hersteller	Leinco Technologies
Menge	500 ug
Quantity options	100 ug 500 ug
Kategorie	Antibodies Flow Cytometry Immunohistochemistry Western Blot Immunofluorescence Primary Antibodies
Typ	Antibody Monoclonal
Applikationen	WB, FC, IF, IHC, other
Clon	DREG56
Specific against	Human (Homo sapiens)
Host	Mouse
NCBI	6402
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Applications	B, FC, IF, IHC FF, PhenoCycler®, WB
Manufacturer - Category	Primary Monoclonal Antibodies>SurfaceTag Human CD Markers
Manufacturer - Targets	CD62L
Country of Origin	USA
Shipping Temperature	Next Day 2 - 8°C
Storage Conditions	This purified antibody is stable when stored at 2-8°C. Do not freeze.
Product Description	CD62L antibody, clone DREG56, recognizes CD62L, also known as L-selectin or LECAM-1, a 74-95 kDa type I transmembrane glycoprotein and cell adhesion molecule expressed on most circulating leukocytes1. Ligands for CD62L include CD34, GlyCAM-1, and MAdCAM-1, which require sialyation, fucosylation, and carbohydrate sulfation for recognition2, 3. Ligand binding mediates tethering and rolling of leukocytes, facilitating entry into secondary lymphoid organs, including lymph nodes and Peyer’s patches, via high endothelial venules (HEVs)1. CD62L is also expressed on human embryo trophoblasts and has been proposed to play a role in human embryo implantation4.
Background	CD62L antibody, clone DREG56, recognizes CD62L, also known as L-selectin or LECAM-1, a 74-95 kDa type I transmembrane glycoprotein and cell adhesion molecule expressed on most circulating leukocytes¹. Ligands for CD62L include CD34, GlyCAM-1, and MAdCAM-1, which require sialyation, fucosylation, and carbohydrate sulfation for recognition^{2, 3}. Ligand binding mediates tethering and rolling of leukocytes, facilitating entry into secondary lymphoid organs, including lymph nodes and Peyer’s patches, via high endothelial venules (HEVs)¹. CD62L is also expressed on human embryo trophoblasts and has been proposed to play a role in human embryo implantation^{4^.}
Function	Leukocyte homing, leukocyte tethering, rolling
Additional Reported Applications For Relevant Conjugates	CODEX®
Other Applications Reported In Literature	IHC FF IF B
PubMed	CD62L
Ligand/Receptor	CD34, GlyCAM, MAdCAM-1
Manufacturer - Research Area	Cell Adhesion, Cell Biology, Costimulatory Molecules, Immunology, Innate Immunity
Manufacturer - Specificity	Clone DREG56 recognizes an epitope on human CD62L.
RRID	AB_2829223
Concentration	0.5 mg/ml
Formulation	This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Antigen Distribution	CD62L is expressed on most circulating leukocytes, including neutrophils, monocytes, T, B and NK cells, and human embryo trophoblasts.
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	Monoclonal Antibody, L-Selectin, Mel-14, LAM-1, LEU-8, DREG56, CD62L, Human, Anti-Human CD62L (L-Selectin) - Purified

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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LEIN-C2140-500ug-safety-datasheet.pdf