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Anti-Mouse PD-L2 (B7-DC) - Purified in vivo GOLD™ Functional Grade

Anti-Mouse PD-L2 (B7-DC) - Purified in vivo GOLD™ Functional Grade

ArtNr	LEIN-C2292-25mg
Hersteller	Leinco Technologies
Menge	25 mg
Quantity options	1 mg 100 mg 25 mg 5 mg 50 mg
Kategorie	In Vivo Antibodies Primary Antibodies
Typ	Antibody Primary
Applikationen	WB, FC, IP, IHC, IV
Clon	TY25
Specific against	Mouse (Murine, Mus musculus)
Host	Rat
Purity	≥95% monomer by analytical SEC, > 95% by SDS Page
NCBI	58205
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Applications	Quality Tested by Leinco FC The suggested concentration for this CD273 antibody clone TY25 for staining cells in flow cytometry is ≤ 0.25 μg per 10⁶ cells in a volume of 100 μl. Titration of the reagent is recommended for optimal performance for each application. WB
Manufacturer - Category	Purified in vivo Functional Grade>Gold Purified Bulk Antibodies\|Primary Monoclonal Antibodies>Immune Checkpoints\|Primary Monoclonal Antibodies>Surfacetag Mouse CD Markers
Manufacturer - Targets	PD-L2
Country of Origin	USA
Shipping Temperature	Next Day 2-8°C
Storage Conditions	Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
Product Description	PD-L2 antibody, clone TY25, recognizes mouse programmed death ligand 2 (PDL-2), also known as B7-DC and CD273. PD-L2 is a 42 kDa type I transmembrane glycoprotein that belongs to the B7 family of the immunoglobulin (Ig) receptor superfamily. PD-L2 is an inhibitory ligand primarily expressed on antigen-presenting cells, including macrophages and a subset of dendritic cells (DCs). Its receptor, PD-1, is expressed by CD4-CD8- thymocytes as well as CD4 and CD8 T cells, monocytes, DCs, and B cells upon activation1. Binding of PD-L2 to PD-1 on CD4 and CD8 T cells inhibits T cell receptor (TCR) signaling, negatively regulating T cell proliferation, cytokine production, and cytotoxic activity2. PD-L2 is expressed on many tumor types3, 4 and is associated with unfavorable prognosis in patients with solid tumors5.
Background	PD-L2 antibody, clone TY25, recognizes mouse programmed death ligand 2 (PDL-2), also known as B7-DC and CD273. PD-L2 is a 42 kDa type I transmembrane glycoprotein that belongs to the B7 family of the immunoglobulin (Ig) receptor superfamily. PD-L2 is an inhibitory ligand primarily expressed on antigen-presenting cells, including macrophages and a subset of dendritic cells (DCs). Its receptor, PD-1, is expressed by CD4-CD8- thymocytes as well as CD4 and CD8 T cells, monocytes, DCs, and B cells upon activation¹. Binding of PD-L2 to PD-1 on CD4 and CD8 T cells inhibits T cell receptor (TCR) signaling, negatively regulating T cell proliferation, cytokine production, and cytotoxic activity². PD-L2 is expressed on many tumor types^{3, 4} and is associated with unfavorable prognosis in patients with solid tumors⁵.
Other Applications Reported In Literature	IHC FF IP
PubMed	PD-L2
Ligand/Receptor	PD-1, uncharacterized receptor
Manufacturer - Research Area	Costimulatory Molecules, Immunology
Manufacturer - Specificity	Clone TY25 recognizes an epitope on mouse PD-L2. TY25 does not cross-react with PD-L1.
RRID	AB_2749822
Concentration	≥ 5.0 mg/ml
Formulation	This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Product Preparation	Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Antigen Distribution	PD-L2 is expressed on macrophages and a subset of dendritic cells (DCs).
Immunogen	Purified transfected mouse B7-DC cell line
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

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LEIN-C2292-25mg-safety-datasheet.pdf