Anti-Mouse CD252 (OX40L) - Purified in vivo GOLD™ Functional Grade

Quality Tested by Leinco FC For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. Each lot of this antibody is quality control tested.

CD252

Next Day 2-8°C

CD252 is a 35 kD member of the TNF superfamily and is the ligand for OX-40, which is primarily found on activated T cells. The CD252/OX-40 pair contributes to B-cell and T-cell interaction during the immune response. Both proliferative and IL-2 production responses of activated T cells are enhanced via OX-40 antigen stimulation, while proliferation and Ig secretion by activated B cells is enhanced via CD252 stimulation. Hence, because both T cells and B cells are activated in cross-linking, the CD252/OX-40 pair is considered reciprocally costimulatory.

B-cell/T-cell interaction, costimulation

CD252

Costimulatory Molecules, Immunology

AB_2737465

This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.

CD252 is expressed on activated B cells and antigen presenting cells.

Rat NRK-52E cell line transfected with mouse OX-40L gene