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Anti-Human CD19 [Clone SJ25-C1] – Purified in vivo GOLD™ Functional Grade - 1.0 mg

Anti-Human CD19 [Clone SJ25-C1] – Purified in vivo GOLD™ Functional Grade - 1.0 mg

ArtNr	LEIN-C2854-1.0mg
Hersteller	Leinco Technologies
Menge	1 mg
Quantity options	1 mg 100 mg 25 mg 5 mg 50 mg
Kategorie	Oncology In Vivo Antibodies By Cell Type Hematology Leukemia Lymphoma Flow Cytometry ELISA Primary Antibodies Immunostaining
Typ	Antibody Monoclonal
Applikationen	FC, ELISA, IV
Clon	SJ25-C1
Specific against	Human (Homo sapiens)
Host	Mouse
Purity	≥95% monomer by analytical SEC
NCBI	930
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Category	Purified in vivo Functional Grade>Gold Purified Bulk Antibodies\|Primary Monoclonal Antibodies>SurfaceTag Human CD Markers
Manufacturer - Targets	CD19
Country of Origin	USA
Shipping Temperature	Next Day 2 - 8°C
Storage Conditions	Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at ≤ -70°C. Avoid Repeated Freeze Thaw Cycles.
Product Description	CD19 is a 95 kD transmembrane glycoprotein and member of the Ig superfamily. The antigen serves as an adaptor protein; drawing cytoplasmic signaling proteins to the membrane. It works via the CD19/CD21 complex to decrease the threshold for B cell receptor signaling pathways. Because of its presence on all B cells, CD19 is a biomarker for B lymphocyte development, lymphoma diagnosis and can be utilized as a target for the immunotherapy of lymphoproliferative disorders. Emerging studies indicate that CD19 plays an active role in fueling the growth of these cancers, most notably by stabilizing the concentrations of the MYC oncoprotein, making CD19 an attractive therapeutic target with respect to its downstream signaling.
Background	CD19 is a 95 kD transmembrane glycoprotein and member of the Ig superfamily. The antigen serves as an adaptor protein; drawing cytoplasmic signaling proteins to the membrane. It works via the CD19/CD21 complex to decrease the threshold for B cell receptor signaling pathways. Because of its presence on all B cells, CD19 is a biomarker for B lymphocyte development, lymphoma diagnosis and can be utilized as a target for the immunotherapy of lymphoproliferative disorders. Emerging studies indicate that CD19 plays an active role in fueling the growth of these cancers, most notably by stabilizing the concentrations of the MYC oncoprotein, making CD19 an attractive therapeutic target with respect to its downstream signaling.
Function	B cell activation and differentiation
PubMed	CD19
Ligand/Receptor	Forms complex with CD21 (CR2) and CD81 (TAPA-1), BCR coreceptor
Manufacturer - Research Area	Costimulatory Molecules, Immunology
Manufacturer - Specificity	Clone SJ25-C1 recognizes an epitope on human CD19.
RRID	AB_2829610
Concentration	≥ 2.0 mg/ml
Formulation	This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Antigen Distribution	CD19 is expressed in the majority of Pro-B cells to mature B cells (during development) and follicular dendritic cells. Plasma cells do not express CD19.
Endotoxin Level	≤ 1.0 EU/mg as determined by the LAL method
Immunogen	NALM1 + NALM16 cells
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	Monoclonal Antibody, CD19, Pan B-Cells, SJ25-C1, Human CD19, Anti-Human CD19, CD19 antibody, CD19 Molecule, CD19 Antigen, Differentiation Antigen CD19, B-Lymphocytes Surface Antigen B4, T-cell Surface Antigen Leu-12, CVID3, B4, B-lymphocyte Antigen CD19, SJ25C1

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LEIN-C2854-1.0mg-safety-datasheet.pdf