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Anti-Mouse CD252 (OX40L) [Clone RM134L] – Purified <i>in vivo </i>PLATINUM™ Functional Grade - 1.0 mg

Anti-Mouse CD252 (OX40L) [Clone RM134L] – Purified <i>in vivo </i>PLATINUM™ Functional Grade - 1.0 mg

ArtNr	LEIN-C6336-1.0mg
Hersteller	Leinco Technologies
Menge	1 mg
Quantity options	1 mg 100 mg 25 mg 5 mg 50 mg
Kategorie	In Vivo Antibodies In Vivo Antibodies Flow Cytometry Immunohistochemistry Western Blot
Typ	Antibody Monoclonal
Applikationen	WB, FC, IHC, other, IV
Clon	RM134L
Specific against	Mouse (Murine, Mus musculus)
Host	Rat
Purity	> 95% by SDS-PAGE and ≥ 98% monomer by analytical SEC
NCBI	22164
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Applications	B, FC, IHC FF, in vivo, WB
Manufacturer - Targets	CD252
Country of Origin	USA
Shipping Temperature	Next Day 2 - 8°C
Storage Conditions	Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at ≤ -70°C. Avoid Repeated Freeze Thaw Cycles.
Product Description	CD252 is a 35 kD member of the TNF superfamily and is the ligand for OX-40, which is primarily found on activated T cells. The CD252/OX-40 pair contributes to B-cell and T-cell interaction during the immune response. Both proliferative and IL-2 production responses of activated T cells are enhanced via OX-40 antigen stimulation, while proliferation and Ig secretion by activated B cells is enhanced via CD252 stimulation. Hence, because both T cells and B cells are activated in cross-linking, the CD252/OX-40 pair is considered reciprocally costimulatory.
Background	CD252 is a 35 kD member of the TNF superfamily and is the ligand for OX-40, which is primarily found on activated T cells. The CD252/OX-40 pair contributes to B-cell and T-cell interaction during the immune response. Both proliferative and IL-2 production responses of activated T cells are enhanced via OX-40 antigen stimulation, while proliferation and Ig secretion by activated B cells is enhanced via CD252 stimulation. Hence, because both T cells and B cells are activated in cross-linking, the CD252/OX-40 pair is considered reciprocally costimulatory.
Pathogen Testing	To protect mouse colonies from infection by pathogens and to assure that experimental preclinical data is not affected by such pathogens, all of Leinco’s Purified Functional PLATINUM™ antibodies are tested and guaranteed to be negative for all pathogens in the IDEXX IMPACT I Mouse Profile.
Function	B-cell/T-cell interaction, costimulation
Other Applications Reported In Literature	B:The RM134L antibody can block the costimulatory activity of OX40L. IHC-FFPE:
PubMed	CD252
Ligand/Receptor	OX40 (CD134)
Manufacturer - Research Area	Costimulatory Molecules, Immunology
Manufacturer - Specificity	Clone RM134L recognizes an epitope on mouse CD252.
RRID	AB_2829790
Concentration	≥ 5.0 mg/ml
Formulation	This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Product Preparation	Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Antigen Distribution	CD252 is expressed on activated B cells and antigen presenting cells.
Endotoxin Level	≤ 0.5 EU/mg
Immunogen	Rat NRK-52E cell line transfected with mouse OX-40L gene
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	Monoclonal Antibody, OX 40 Ligand, OX 40 Ligand, OX40L, CD134L, TNFSF4, RM134L, CD252, Mouse CD252, Anti-Mouse CD252 (OX40L) - Purified Low Endotoxin Functional Formulation, CD134 ligand, CD134L, CD252 antigen, CD252, Glycoprotein Gp34, gp34, OX40 antigen ligand, OX40 Ligand, OX40L, OX-40L, OX4OL, TAX transcriptionally-activated glycoprotein 1, tax-transcriptionally activated glycoprotein 1 34kD, tax-transcriptionally activated glycoprotein 1 34kD, TNFSF4, tumor necrosis factor ligand superfamily member 4, tumor necrosis factor ligand superfamily member 4, TXGP1

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LEIN-C6336-1.0mg-safety-datasheet.pdf