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Anti-Human DR5 (CT) - 0.1 mg

ArtNr LEIN-D251-0.1mg
Hersteller Leinco Technologies
Menge 0.1 mg
Quantity options 0.1 mg 20 ug
Kategorie
Typ Antibody Primary
Applikationen WB, IHC, ICC
Specific against Human (Homo sapiens)
Host Rabbit
Citations 1. Pan, G. et al. (1997) Science 277:815-8
2. Sheridan, JP. et al. (1997) Science 277:818-21
3. Walczak, H. et al. (1997) EMBO J 16:5386-97
4. MacFarlane, M. et al. (1997) J Biol Chem 272:25417-20
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Versandbedingung Raumtemperatur
Lieferbar
Manufacturer - Applications
ICC, IHC FFPE, WB
Manufacturer - Category
Primary Monoclonal Antibodies>Apoptosis & Cell Biology
Manufacturer - Targets
DR5
Country of Origin
USA
Shipping Temperature
Next Day Ambient
Storage Conditions
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Product Description
Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family. DR4 was recently identified as the receptor for TRAIL. A novel death domain containing receptor for TRAIL was more recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2, or KILLER by several groups independently.1-4 Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. DR5 binds to TRAIL and mediates TRAIL induced cell death. Overexpression of DR5 induces apoptosis and activates NF-κB.
Background
Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family. DR4 was recently identified as the receptor for TRAIL. A novel death domain containing receptor for TRAIL was more recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2, or KILLER by several groups independently.1-4 Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. DR5 binds to TRAIL and mediates TRAIL induced cell death. Overexpression of DR5 induces apoptosis and activates NF-κB.
PubMed
DR5
Manufacturer - Specificity
Rabbit Anti-Human DR5 recognizes an epitope near the C-terminus of mouse and human DR5. This polyclonal antibody was purified using affinity chromatography.
RRID
AB_2829905
Concentration
0.5 mg/ml
Formulation
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Immunogen
PN:D279
Additional Information
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords
Polyclonal Antibody, DR5, Apo2, TRAIL-R2, TRICK2, KILLER, Human TRAIL, Anti-Human DR5 (CT), DR5 Antibody, DR5, CD262, KILLER, TRICK2, TRICKB, ZTNFR9, TRAILR2, TRICK2A, TRICK2B, TRAIL-R2, KILLER/DR5, DR5, UNQ160/PRO186, Tumor necrosis factor receptor superfamily member 10B, Death receptor 5, TRAIL receptor 2

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 0.1 mg
Lieferbar: In stock
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