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Anti-Human FGF-Acidic - 100 µg

Anti-Human FGF-Acidic - 100 µg

ArtNr	LEIN-F106-100ug
Hersteller	Leinco Technologies
Menge	100 ug
Quantity options	100 ug 25 ug
Kategorie	Antibodies Immunohistochemistry Western Blot Primary Antibodies
Typ	Antibody Primary
Applikationen	WB, IHC
Specific against	Human (Homo sapiens)
Host	Caprine
Citations	1. Jaye, M. et al. (1986) Science 233:541 2. Otlewski, J. et al. (2009) Acta. Crystallogr. D. Biol. Crystallogr. 65:67 3. Nakazawa, F. et al. (2006) Blood. 108:3335 4. Bjornsson, TD. et al. (1991) Proc. Natl. Acad. Sci. (USA) 88:8651 5. Merwin, JR. et al. (1992) Cancer Res. 52:4995
NCBI	2246
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Applications	IHC FFPE, N, WB
Manufacturer - Category	Polyclonal Antibodies>Growth Factors & Cytokines
Manufacturer - Targets	FGF-Acidic
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	The lyophilized antigen affinity purified polyclonal antibody can be stored desiccated at -20°C to -70°C for twelve months from date of receipt. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. No detectable loss of activity was observed after six months.
Product Description	Fibroblast growth factor 1 (acidic), also known as FGF1, is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF-1 is the only member of the FGF family that binds with high affinity to all four FGF receptors.1FGF1 plays an important role in hematopoietic stem cell homeostasis. The FGF pathway regulates primitive hematopoiesis by modulating transcription factors such as Gata1 expression level and activity.2
Background	Fibroblast growth factor 1 (acidic), also known as FGF1, is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF-1 is the only member of the FGF family that binds with high affinity to all four FGF receptors.¹FGF1 plays an important role in hematopoietic stem cell homeostasis. The FGF pathway regulates primitive hematopoiesis by modulating transcription factors such as Gata1 expression level and activity.²
Other Applications Reported In Literature	IHC (NBF/Par.): This antibody should give satisfactory staining results when used at a concentration of 1.7 µg/ml. The recommended secondary antibody for IHC is PN:G505. For chromogenic detection with high signal and low background use PN:D100 or PN:K107. Neutralization: This antibody is useful for neutralization of Human FDF-Acidic bioactivity. The antibody dose required to neutralize 50% (ND₅₀) of the biological activity of Human FDF-Acidic (at 0.75 ng/ml) is 0.25 - 0.75 µg/ml.
PubMed	FGF-Acidic
Manufacturer - Specificity	Goat Anti-Human FGF Acidic recognizes Human FGF Acidic. This antigen affinity purified polyclonal antibody was purified using a proprietary chromatographic technique that includes covalently immobilizing the antigen proteins or peptides to agarose based beads. This purification method enhances specificity, reduces nonspecific binding of extraneous IgG and provides you with the most reliable reagent available for your early discovery research.
RRID	AB_2830103
Formulation	This antigen affinity purified polyclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 containing 5.0% w/v trehalose with no calcium, magnesium, or preservatives present.
Endotoxin Level	< 0.1 EU/µg as determined by the LAL method
Immunogen	Purified Recombinant Human FDF-acidic (> 98%)
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	Polyclonal Antibody, FGF Acidic, FGF-1, ECGF, HBGF-1, AFGF, ECGF-Beta, ECGFA, ECGFB, FGF-alpha, FGFA, GLIO703, Human FGF-Acidic, Anti-Human FGF-Acidic, AFGF; alpha, alpha-ECGF, beta-ECGF, ECGF, ECGFB, ECGF-betaAcidic fibroblast growth factor, endothelial cell growth factor, beta, FGF acidic, FGF1, FGF-1, FGFABeta-endothelial cell growth factor, FGF-alpha, fibroblast growth factor 1 acidic, GLIO703, HBGF1, HBGF-1, heparin-binding growth factor 1

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LEIN-F106-100ug-safety-datasheet.pdf