Anti-Mouse Fas Ligand (Clone 101626) - 25 µg

ELISA Cap, N, WB

Fas Ligand

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Fas ligand (FasL) is a type II transmembrane protein that belongs to the tumor necrosis factor (TNF) family. Fas ligand is a homotrimeric protein and signals through trimerization of FasR, which spans the membrane of the "target" cell. This trimerization usually leads to apoptosis, or cell death. Soluble Fas ligand is generated by cleaving membrane-bound FasL at a conserved cleavage site by the external serine matrix metalloproteinase MMP-7. Soluble FasL is less active than their membrane-bound counterparts and do not induce receptor trimerization and DISC formation. FasL is regarded as a potential target for immunotherapy.1

Neutralization: This antibody is useful for neutralization of Mouse Fas Ligand bioactivity. The antibody dose required to neutralize 50% (ND₅₀) of the biological activity of Mouse Fas Ligand (at 5 ng/ml) is 5 - 20 µg/ml.

Rat Anti-Mouse Fas Ligand (Clone 101626) recognizes an epitope on Mouse Fas Ligand. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present.

Purified Recombinant Mouse FAS Ligand (> 98%)

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