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Anti-Human FLASH (CT) - 0.1 mg

Anti-Human FLASH (CT) - 0.1 mg

ArtNr	LEIN-F138-0.1mg
Hersteller	Leinco Technologies
Menge	0.1 mg
Quantity options	0.1 mg 20 ug
Kategorie	Antibodies Immunohistochemistry Western Blot Primary Antibodies
Typ	Antibody Primary
Applikationen	WB, IHC
Specific against	Human (Homo sapiens)
Host	Rabbit
Citations	1. Imai, Y. et al. (1999) Nature 398:777-85 2. Koonin, EV. et al. (1999) Nature 401:662-3 3. Medema JP. (1999) Nature. 398(6730):756-7.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Applications	IHC FFPE, WB
Manufacturer - Category	Primary Monoclonal Antibodies>Apoptosis & Cell Biology
Manufacturer - Targets	FLASH
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Product Description	A novel mammalian CED-4 homologous was recently identified and cloned in mouse1 and human2 and designated FLASH (for FLICE-associated huge protein). FLASH is involved in Fas induced apoptosis. It is recruited to Fas after the receptor cross-linking. Overexpression of wild type of FLASH facilitates and its dominant negative form inhibits Fas induced apoptosis. FLASH interacts with the DEDs of caspase-8 and FADD through the DED-like domain of FLASH and mediates activation of caspase-8.1 There are parallels between FLASH and Apaf-1/CED-4 although there are arguments against their structural similarity.1, 2 FLASH is widely expressed.
Background	A novel mammalian CED-4 homologous was recently identified and cloned in mouse¹ and human² and designated FLASH (for FLICE-associated huge protein). FLASH is involved in Fas induced apoptosis. It is recruited to Fas after the receptor cross-linking. Overexpression of wild type of FLASH facilitates and its dominant negative form inhibits Fas induced apoptosis. FLASH interacts with the DEDs of caspase-8 and FADD through the DED-like domain of FLASH and mediates activation of caspase-8.¹ There are parallels between FLASH and Apaf-1/CED-4 although there are arguments against their structural similarity.^{1, 2} FLASH is widely expressed.
PubMed	FLASH
Manufacturer - Specificity	Rabbit Anti-Human FLASH recognizes and epitope near the C-terminus of Human FLASH. This polyclonal antibody was purified using affinity chromatography.
RRID	AB_2830177
Concentration	0.5 mg/ml
Formulation	This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Immunogen	PN:F145
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	Polyclonal Antibody, FLICE-Associated Huge Protein, FLICE Associated Huge Protein, FLASH, Human, Anti-Human FLASH (CT), FLASH Antibody, CED-4, FLASH, RIP25, KIAA1315, CASP8-associated protein 2, FLICE-associated huge protein

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LEIN-F138-0.1mg-safety-datasheet.pdf