Anti-Mouse GFRα-3 (Intermediate Domain) - 0.1 mg

IHC FFPE, WB

Glial Cell Line-Derived Neurotropic Factor Receptor Alpha 3

Next Day Ambient

GDNF family receptor alpha 3, also known as GFRA3 is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the ligand, artemin. GFRalpha3 preferentially binds the newest member of the glial-derived neurotrophic factor family of ligands, artemin. The major site of GFRalpha3 expression is in the dorsal root ganglion. GFRalpha3 artemin neurons are immunopositive for markers expected of nociceptors and include a subset of neurons distinct from the GDNF-responsive population.1glycosylphosphadidylinositol linked protein GFRα and Ret receptor tyrosine kinase GFRβ (2). Following the findings of GFRα-1 and -2, a novel receptor in GFRα family was identified very recently from human and mouse and designated GFRα-3 (3-7). GFRα-3 binds persephin, thus, persephin, GFRα-3, and Ret PTK form a complex to transduce persephin signal and to mediate persephin function.

Glial Cell Line-Derived Neurotropic Factor Receptor Alpha 3

AB_2830237

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.