Anti-Human I-Kappa-B Kinase Epsilon (CT) (IKKε) - 0.1 mg

IHC FFPE, WB

I-Kappa-B Kinase Epsilon

Next Day Ambient

Nuclear factor kappa B (NF-κB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κB mediates the expression of a great variety of genes in response to extracellular stimuli. NF-κB is associated with IkB proteins in the cell cytoplasm, which inhibit NF-κB activity. IkB is phosphorylated by IkB kinase (IKK) complex that contains IKKα, IKKβ, and IKKγ. A novel molecule in the IKK complex was recently identified and designated IKKε/IKK-i.1, 2 IKKe is required for the activation of NF-κB by PMA and T cell receptors but not by TNFα and IL-1.1 IKKε/IKK-i message is supexpressed in a variety of tissues and is inducible by TNFα, IL-1, and LPS.2

I-Kappa-B Kinase Epsilon

AB_2830624

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.