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Anti-Human I-Kappa-B Kinase Gamma (NT) (IKKgamma)

Anti-Human I-Kappa-B Kinase Gamma (NT) (IKKgamma)

ArtNr	LEIN-I-304-1mg
Hersteller	Leinco Technologies
Menge	1 mg
Quantity options	0.1 mg 0.5 mg 1 mg 20 ug
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Specific against	Human (Homo sapiens)
Host	Rabbit
Citations	1. Rothwarf, DM. et al. (1998) Nature 395(6699):297 2. Yamaoka, S. et al. (1998) Cell 93(7):1231 3. Li, Y. et al. (1999) Proc. Natl. Acad. Sci. USA 96(3):1042 4. Mercurio, F. et al. (1999) Mol. Cell Biol. 19(2):1526
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Category	Primary Monoclonal Antibodies>Apoptosis & Cell Biology
Manufacturer - Targets	I-Kappa-B Kinase Gamma
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Product Description	Nuclear factor kappa B (NF-κB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κB mediates the expression of a great variety of genes in response to extracellular stimuli. NF-κB is associated with IkB proteins in the cell cytoplasm, which inhibit NF-κB activity. The IkB kinase (IKKα and IKKβ) phosphorylates IkB and mediates NF-κB activation. A novel molecule in the IKK complex was recently identified and termed IKKγ/NEMO/FIP3/IKKAP1.1-4 IKKg interacts with IKKβ and is required for the activation of IKK complex and NF-κB by LPS, PMA, TNF, and IL-1 stimulation.1-4 FIP3 was also shown to bind to RIP and NIK and to mediate TNF-induced NF-κB activation.3
Background	Nuclear factor kappa B (NF-κB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κB mediates the expression of a great variety of genes in response to extracellular stimuli. NF-κB is associated with IkB proteins in the cell cytoplasm, which inhibit NF-κB activity. The IkB kinase (IKKα and IKKβ) phosphorylates IkB and mediates NF-κB activation. A novel molecule in the IKK complex was recently identified and termed IKKγ/NEMO/FIP3/IKKAP1.^1-4 IKKg interacts with IKKβ and is required for the activation of IKK complex and NF-κB by LPS, PMA, TNF, and IL-1 stimulation.^1-4 FIP3 was also shown to bind to RIP and NIK and to mediate TNF-induced NF-κB activation.³
PubMed	I-Kappa-B Kinase Gamma
Manufacturer - Specificity	Rabbit Anti-Human I-Kappa-B Kinase Gamma (IKKγ) recognizes an epitope near the N-terminus of Human, Mouse and Rat IKKγ. This polyclonal antibody was purified using affinity chromatography.
RRID	AB_2830625
Concentration	0.5 mg/ml
Formulation	This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Immunogen	PN:I-318
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

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LEIN-I-304-1mg-safety-datasheet.pdf