Anti-Mouse IL-13 - 100 µg

ICC, N, WB

IL-13

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Interleukin 13 (IL-13) is a cytokine secreted by many cell types, but especially T helper type 2 (Th2) cells1, that is an important mediator of allergic inflammation and disease. IL-13 induces its effects through a multi-subunit receptor that includes the alpha chain of the IL-4 receptor (IL-4Rα), which is also a component of the IL-4 receptor, and at least one of two known IL-13-specific binding chains.1 The functions of IL-13 overlap considerably with those of IL-4. Although IL-13 is associated primarily with the induction of airway disease, it also has anti-inflammatory properties. IL-13 induces many features of allergic lung disease, including airway hyperresponsiveness, goblet cell metaplasia and mucus hypersecretion, which all contribute to airway obstruction.

Immunocytochemistry: This antibody will detect IL-13 in cells. The working dilution is 5 - 15 μg/ml.
Neutralization: This antibody is useful for neutralization of Mouse IL-13 bioactivity. The antibody dose required to neutralize 50% (ND₅₀) of the biological activity of Mouse IL-13 (at 10 ng/ml) is 0.05 - 0.15 µg/ml.

Other Molecules

AB_2830643

< 0.01 EU/µg as determined by the LAL method

Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.