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Anti-Human Interferon Regulatory Factor 7 (Intermediate Domain) - 0.1 mg

Anti-Human Interferon Regulatory Factor 7 (Intermediate Domain) - 0.1 mg

ArtNr	LEIN-I-523-0.1mg
Hersteller	Leinco Technologies
Menge	0.1 mg
Quantity options	0.1 mg 20 ug
Kategorie	Antibodies Immunohistochemistry Western Blot Primary Antibodies
Typ	Antibody Primary
Applikationen	WB, IHC
Specific against	Human (Homo sapiens)
Host	Rabbit
Citations	1. Malmgaard, L. (2004) J. Interferon & Cyto. Res. 24:439 2. Sato, M. et al. (2000) Immunity 2000 13:539 3. Fitzgerald, KA. et al. (2003) J. Exp. Med. 198:1043 4. Honda, K. et al. (2004) Proc. Natl. Acad. Sci. USA 101:15416
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Applications	IHC FFPE, WB
Manufacturer - Category	Primary Monoclonal Antibodies>Apoptosis & Cell Biology
Manufacturer - Targets	Interferon Regulatory Factor 7
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Product Description	Interferons (IFNs) are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms (1 for review). During infection, hostvirus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3)which can act to st imulate transcription of IFN-α/β genes. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, includinginterferon beta chain genes (2). IRF7 play a major role in the innate immune pathway, interacting with the Toll-like receptor (TLR) adaptor proteins MyD88 and Tirp/TRAM and functioning as an intermediate TLR4 and TLR9 signaling(3, 4). There are at least four differentially spliced isoforms of IRF7, although their function has not been clearly established.
Background	Interferons (IFNs) are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms (1 for review). During infection, hostvirus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3)which can act to st imulate transcription of IFN-α/β genes. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes (2). IRF7 play a major role in the innate immune pathway, interacting with the Toll-like receptor (TLR) adaptor proteins MyD88 and Tirp/TRAM and functioning as an intermediate TLR4 and TLR9 signaling (3, 4). There are at least four differentially spliced isoforms of IRF7, although their function has not been clearly established.
PubMed	Interferon Regulatory Factor 7
Manufacturer - Specificity	Rabbit Anti-Human Interferon Regulatory Factor 7 (IRF7) recognizes an epitope near the center of Human IRF7. This polyclonal antibody was purified using affinity chromatography.
RRID	AB_2830721
Concentration	0.5 mg/ml
Formulation	This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

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LEIN-I-523-0.1mg-safety-datasheet.pdf